- Title
- Association of Islet Amyloid Polypeptide to C-Peptide Ratio with Cystic Fibrosis-Related Diabetes: A Prospective Cross-sectional Study
- Creator
- Thota, Rohith N.; Wynne, Katie; Pradeepan, Shyamala; Wark, Peter A. B.; Garg, Manohar L.
- Relation
- Pancreas Vol. 51, Issue 8, p. 1029-1036
- Publisher Link
- http://dx.doi.org/10.1097/MPA.0000000000002134
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 2022
- Description
- Objectives: Early detection of cystic fibrosis (CF) related diabetes (CFRD) improves health outcomes and reduces CF-related mortality. The study aims to evaluate the ratio of islet amyloid polypeptide (IAPP) to C-peptide in CF patients with diabetes and without diabetes. Methods: Cross-sectional analysis was carried out in a prospective cohort of 33 participants (CF [n=16] and CFRD [n=18]). We examined the association of plasma IAPP:C-peptide ratio with clinical information, including glycated hemoglobin, and lung function markers. Results: The median (interquartile range) IAPP:C-peptide ratio was significantly (P=0.004) higher in people with CFRD (4.8 [4.5]) compared with participants without CFRD (12.1 [19.7]). The ratio of IAPP to C-peptide significantly accounted for a 38% variation in the diabetes status in patients with CF (r2=0.399, P < 0.001). Islet amyloid polypeptide is strongly correlated with serum ferritin levels (r=0.683, P=0.005) and forced expiratory volume in CFRD, but not in nondiabetic participants with CF. Conclusions: Islet amyloid polypeptide:C-peptide ratio could be a potential marker of CFRD in adults with CF. Further research requires validation of this marker in longitudinal cohort studies to confirm the capability of IAPP:C-peptide to predict CFRD.
- Subject
- cystic fibrosis; diabetes; C-peptide; islet amyloid polypeptide; cross-sectional study; blood biomarkers; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1487893
- Identifier
- uon:52281
- Identifier
- ISSN:0885-3177
- Language
- eng
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